Karsten Wassermann Selected Research

ragaglitazar

9/2006	The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients.
2/2005	The dual PPARalpha/gamma agonist, ragaglitazar, improves insulin sensitivity and metabolic profile equally with pioglitazone in diabetic and dietary obese ZDF rats.
9/2003	Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis.
4/2003	Dual PPARalpha /gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats.
3/2003	PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly.

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Karsten Wassermann Research Topics

Disease

6	Insulin Resistance 09/2006 - 02/2002
4	Type 2 Diabetes Mellitus (MODY) 01/2019 - 04/2003
2	Obesity 02/2005 - 09/2003
1	Diabetes Mellitus 11/2019
1	Weight Gain 10/2008
1	Cardiomegaly (Heart Hypertrophy) 10/2008
1	Edema (Dropsy) 09/2006
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 06/2006
1	Overweight 06/2006
1	Coronary Occlusion 06/2006
1	Hyperglycemia 04/2003
1	Hepatomegaly 03/2003
1	Fatty Liver 03/2003
1	Postmenopausal Osteoporosis 01/2002

Drug/Important Bio-Agent (IBA)

6	Insulin (Novolin)FDA Link 11/2019 - 03/2003
5	PPAR gammaIBA 10/2008 - 02/2002
5	PPAR alphaIBA 09/2006 - 03/2003
5	ragaglitazarIBA 09/2006 - 03/2003
4	Rosiglitazone (Avandia)FDA Link 10/2008 - 02/2002
4	Pioglitazone (Actos)FDA Link 09/2006 - 02/2002
3	Glucose (Dextrose)FDA LinkGeneric 06/2006 - 04/2003
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2019 - 09/2003
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 09/2006 - 04/2003
2	Triglycerides (Triacylglycerol)IBA 04/2003 - 03/2003
1	Metformin (Glucophage)FDA LinkGeneric 01/2019
1	Insulin Glargine (Lantus)FDA Link 01/2019
1	2,4-thiazolidinedione (thiazolidinedione)IBA 10/2008
1	balaglitazoneIBA 10/2008
1	ThiazolidinedionesIBA 09/2006
1	muraglitazarIBA 09/2006
1	Fatty Acids (Saturated Fatty Acids)IBA 06/2006
1	LeptinIBA 06/2006
1	AdiponectinIBA 06/2006
1	BezafibrateIBA 02/2005
1	PPAR-gamma AgonistsIBA 09/2003
1	Fenofibrate (CiL)FDA LinkGeneric 09/2003
1	LipidsIBA 04/2003
1	pirinixic acidIBA 03/2003
1	Estrogens (Estrogen)FDA Link 01/2002

Therapy/Procedure

1	Therapeutics 02/2005
1	Glycemic Control 04/2003
1	Aftercare (After-Treatment) 04/2003